Ursane-type triterpenoids from the roots of Rosa multiflora with their anti-inflammatory activity.

Nine ursane-type triterpenoids including three new ones 2 α , 19 α- dihydroxyurs-3 -O- acetyltormentic acid ( 1 ), 1 α , 2 α , 3 α , 20 β -tetrahydroxyurs -13(18)-en-28-oic acid ( 2 ), and 2 α , 3 α , 20 β , 24-tetrahydroxyurs-13(18)-en-28-oic acid ( 3 ) were isolated from the roots of Rosa multiflora . Their structures were elucidated by extensive spectroscopic methods, including NMR, MS, and IR spectroscopic analyses data. All the isolates were evaluated for their anti-inflammatory activity in vitro and the results showed that compounds 1 - 9 displayed moderate inhibitory activity with IC ₅₀ values ranging from 24.7 to 86.2 μM compared with the postitive control Amino guanidine (IC ₅₀ 4.3 μM).[Formula: see text].