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General and Abdominal Obesity and Incident Distal Sensorimotor Polyneuropathy: Insights Into Inflammatory Biomarkers as Potential Mediators in the KORA F4/FF4 Cohort.

Authors :
Schlesinger S
Herder C
Kannenberg JM
Huth C
Carstensen-Kirberg M
Rathmann W
Bönhof GJ
Koenig W
Heier M
Peters A
Meisinger C
Roden M
Thorand B
Ziegler D
Source :
Diabetes care [Diabetes Care] 2019 Feb; Vol. 42 (2), pp. 240-247. Date of Electronic Publication: 2018 Dec 06.
Publication Year :
2019

Abstract

Objective: To investigate the associations between different anthropometric measurements and development of distal sensorimotor polyneuropathy (DSPN) considering interaction effects with prediabetes/diabetes and to evaluate subclinical inflammation as a potential mediator.<br />Research Design and Methods: This study was conducted among 513 participants from the Cooperative Health Research in the Region of Augsburg (KORA) F4/FF4 cohort (aged 62-81 years). Anthropometry was measured at baseline. Incident DSPN was defined by neuropathic impairments using the Michigan Neuropathy Screening Instrument at baseline and follow-up. Associations between anthropometric measurements and DSPN were estimated by multivariable logistic regression. Potential differences by diabetes status were assessed using interaction terms. Mediation analysis was conducted to determine the mediation effect of subclinical inflammation in these associations.<br />Results: After a mean follow-up of 6.5 years, 127 cases with incident DSPN were detected. Both general and abdominal obesity were associated with development of DSPN. The odds ratios (95% CI) of DSPN were 3.06 (1.57; 5.97) for overweight, 3.47 (1.72; 7.00) for obesity (reference: normal BMI), and 1.22 (1.07; 1.38) for 5-cm differences in waist circumference, respectively. Interaction analyses did not indicate any differences by diabetes status. Two chemokines (C-C motif chemokine ligand 7 [CCL7] and C-X-C motif chemokine ligand 10 [CXCL10]) and one neuron-specific marker (Delta/Notch-like epidermal growth factor-related receptor [DNER]) were identified as potential mediators, which explained a proportion of the total effect up to 11% per biomarker.<br />Conclusions: General and abdominal obesity were associated with incident DSPN among individuals with and without diabetes, and this association was partly mediated by inflammatory markers. However, further mechanisms and biomarkers should be investigated as additional mediators to explain the remainder of this association.<br /> (© 2018 by the American Diabetes Association.)

Details

Language :
English
ISSN :
1935-5548
Volume :
42
Issue :
2
Database :
MEDLINE
Journal :
Diabetes care
Publication Type :
Academic Journal
Accession number :
30523031
Full Text :
https://doi.org/10.2337/dc18-1842