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Effectiveness of influenza and pneumococcal polysaccharide vaccines against influenza-related outcomes including pneumonia and acute exacerbation of cardiopulmonary diseases: Analysis by dominant viral subtype and vaccine matching.
- Source :
-
PloS one [PLoS One] 2018 Dec 06; Vol. 13 (12), pp. e0207918. Date of Electronic Publication: 2018 Dec 06 (Print Publication: 2018). - Publication Year :
- 2018
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Abstract
- Background: Influenza and pneumonia are leading causes of morbidity and mortality among the elderly. Although vaccination is a main strategy to prevent these infectious diseases, concerns remain with respect to vaccine effectiveness.<br />Methods: During three influenza seasons (2014-2015, 2015-2016 and 2016-2017), we evaluated the effectiveness of the influenza and pneumococcal vaccines against pneumonia and acute exacerbation of cardiopulmonary diseases among the elderly aged ≥65 years with influenza-like illness (ILI). Demographic and clinical data were collected prospectively.<br />Results: Among 2,119 enrolled cases, 1,302 (61.4%) and 871 (41.1%) received the influenza vaccine and 23-valent pneumococcal polysaccharide vaccine (PPV23), respectively. During an A/H3N2-dominant season with poor influenza vaccine effectiveness (2014-2015 season), neither the influenza vaccine nor PPV23 showed significant effectiveness against pneumonia or acute exacerbation of cardiopulmonary diseases. During seasons with good influenza vaccine effectiveness (2015-2016 and 2016-2017 seasons), the influenza vaccine was effective in preventing pneumonia, but PPV23 was not. In particular, the influenza vaccine was effective in preventing acute exacerbation of heart diseases (75.0%) during the A/H1N1-dominant 2015-2016 season.<br />Conclusion: The influenza vaccine was effective in preventing pneumonia only during vaccine-matched seasons with good effectiveness against circulating influenza viruses. In addition, the influenza vaccine was cardio-protective during a vaccine-matched A/H1N1-dominant season.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Acute Disease
Aged
Aged, 80 and over
Cardiovascular Diseases epidemiology
Cohort Studies
Female
Humans
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Influenza, Human epidemiology
Influenza, Human virology
Lung Diseases epidemiology
Male
Pneumonia, Pneumococcal epidemiology
Prospective Studies
Republic of Korea epidemiology
Treatment Outcome
Cardiovascular Diseases prevention & control
Influenza Vaccines pharmacology
Influenza, Human prevention & control
Lung Diseases prevention & control
Pneumococcal Vaccines pharmacology
Pneumonia, Pneumococcal prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 13
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 30521553
- Full Text :
- https://doi.org/10.1371/journal.pone.0207918