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RecurrentĀ ImplantationĀ Failure-update overview on etiology, diagnosis, treatment and future directions.
- Source :
-
Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2018 Dec 05; Vol. 16 (1), pp. 121. Date of Electronic Publication: 2018 Dec 05. - Publication Year :
- 2018
-
Abstract
- Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age and embryo stage into consideration. The failure of embryo implantation can be a consequence of uterine, male, or embryo factors, or the specific type of IVF protocol. These cases should be investigated to determine the most likely etiologies of the condition, as this is a complex problem with several variables. There are multiple risk factors for recurrent implantation failure including advanced maternal age, smoking status of both parents, elevated body mass index, and stress levels. Immunological factors such as cytokine levels and presence of specific autoantibodies should be examined, as well as any infectious organisms in the uterus leading to chronic endometritis. Uterine pathologies such as polyps and myomas as well as congenital anatomical anomalies should be ruled out. Sperm analysis, pre-implantation genetic screening and endometrial receptivity should be considered and evaluated, and IVF protocols should be tailored to specific patients or patient populations. Treatment approaches should be directed toward individual patient cases. In addition, we suggest considering a new initial step in approach to patients with RIF, individualized planned activities to activate the brain's reward system in attempt to improve immunological balance in the body.
- Subjects :
- Embryo Transfer methods
Endometritis etiology
Endometritis therapy
Female
Fertilization in Vitro methods
Humans
Infertility, Female etiology
Infertility, Female therapy
Preimplantation Diagnosis
Recurrence
Risk Factors
Treatment Failure
Embryo Implantation physiology
Endometritis diagnosis
Infertility, Female diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1477-7827
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Reproductive biology and endocrinology : RB&E
- Publication Type :
- Academic Journal
- Accession number :
- 30518389
- Full Text :
- https://doi.org/10.1186/s12958-018-0414-2