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Efficient synthesis of esters through oxone-catalyzed dehydrogenation of carboxylic acids and alcohols.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2018 Dec 12; Vol. 16 (48), pp. 9472-9476. - Publication Year :
- 2018
-
Abstract
- Since esters are important organic synthesis intermediates, an environmentally friendly oxone catalyzed-esterification of carboxylic acids with alcohols has been developed. A series of carboxylic acid esters are obtained in high yield. This strategy requires mild reaction conditions, providing an attractive alternative for the construction of valuable carbonyl esters. Electron-rich and electron-deficient groups are compatible with the standard conditions and a variety of substrates are demonstrated. Moreover, the reaction could easily be adapted to typical prodrugs, drugs and gram-scale synthesis.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 16
- Issue :
- 48
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 30516792
- Full Text :
- https://doi.org/10.1039/c8ob02539h