Back to Search
Start Over
Molecular Threading-Dependent Mass Transport in Paper Origami for Single-Step Electrochemical DNA Sensors.
- Source :
-
Nano letters [Nano Lett] 2019 Jan 09; Vol. 19 (1), pp. 369-374. Date of Electronic Publication: 2018 Dec 10. - Publication Year :
- 2019
-
Abstract
- Molecular transport controls the efficiency of complex biological network systems such as cellular signaling system and cascade biomedical reaction. However, device fabrication for molecular sensing is often restricted by a low transport efficiency and complicated processing. Here, we report a molecular threading-dependent transport system using three-dimensional (3D) paper origami enabling the directional transport of biomolecules. We demonstrate that framework nucleic acid-based interface engineering allows orthogonal molecular recognition and enzymatic reaction with programmed order on site. We thus develop a single-step electrochemical DNA sensor for quantitative analysis with 1 picomolar sensitivity within 60 min. Our sensor can discriminate a mismatched target at the level of a single base mismatch. Our study shows a great potential toward the development of a biomimetic molecular transport system for point-of-care and precision diagnosis.
Details
- Language :
- English
- ISSN :
- 1530-6992
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nano letters
- Publication Type :
- Academic Journal
- Accession number :
- 30511869
- Full Text :
- https://doi.org/10.1021/acs.nanolett.8b04051