SWI/SNF remains localized to chromatin in the presence of SCHLAP1.

Authors :: Raab JR
Smith KN
Spear CC
Manner CJ
Calabrese JM
Magnuson T
Source :: Nature genetics [Nat Genet] 2019 Jan; Vol. 51 (1), pp. 26-29. Date of Electronic Publication: 2018 Dec 03.
Publication Year :: 2019
Abstract: SCHLAP1 is a long noncoding RNA that is reported to function by depleting the SWI/SNF complex from the genome. We investigated the hypothesis that SCHLAP1 affects only specific compositions of SWI/SNF. Using several assays, we found that SWI/SNF is not depleted from the genome by SCHLAP1 and that SWI/SNF is associated with many coding and noncoding RNAs, suggesting that SCHLAP1 may function in a SWI/SNF-independent manner.