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[Short-term safety profile of cross-hormonal therapy in trans-male subjects].
- Source :
-
Medicina [Medicina (B Aires)] 2018; Vol. 78 (6), pp. 399-402. - Publication Year :
- 2018
-
Abstract
- A trans-male (TM) is a biologically female person with male gender identity who wishes to acquire male sexual characteristics and fulfil a male social role. To achieve that purpose, both cross-hormonal therapy (CHT) and surgical phalloplasty can be used. We evaluated the short term (12 months) safety profile of CHT using different forms of testosterone available for prescription in Argentina. In this retrospective study, we analyzed the medical history of 30 trans-male patients fitting the inclusion criteria. The mean age of the population was 27 years. The mean basal serum level of testosterone was 0.43 ng/ml, which increased to 6.36 ng/ml (male hormonal levels). The hematocrit increased from a baseline of 40.0 to 45.2% (p < 0.01) and hemoglobin increased from 13.6 to 15.2 g/dl (p < 0.01). Total cholesterol remained stable with values of 175 and 185 mg/dl (p = 0.81). There were no significant changes in serum triglycerides: 88.3 and 102 mg/dl (p = 0.08). LDL increased in the first 6 to 12 months of CHT from 101.2 to 112.5 mg/dl (p = 0.17). At 12 months HDL levels increased from 50.1 to 52 mg/dl (p < 0.01). Hepatic enzymes remained stable. There is no available data regarding safety of testosterone use in TM in our country. In no case did we need to suspend the medication due to unwanted effects.
- Subjects :
- Adult
Cholesterol blood
Female
Humans
Male
Reference Values
Retrospective Studies
Risk Factors
Statistics, Nonparametric
Testosterone blood
Time Factors
Transsexualism blood
Treatment Outcome
Triglycerides blood
Young Adult
Testosterone therapeutic use
Transgender Persons
Transsexualism drug therapy
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 0025-7680
- Volume :
- 78
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Medicina
- Publication Type :
- Academic Journal
- Accession number :
- 30504106