Back to Search
Start Over
Identification of an immunostimulatory polysaccharide in banana.
- Source :
-
Food chemistry [Food Chem] 2019 Mar 30; Vol. 277, pp. 46-53. Date of Electronic Publication: 2018 Oct 10. - Publication Year :
- 2019
-
Abstract
- Banana is a fruit widely accepted by people over the world. Besides having delicious taste, it shows multiple health benefits. In this work, the major polysaccharide was isolated from banana and purified. It was identified to be α-(1 → 6)-d-glucan. The in vivo immunomodulatory activity assay indicated that α-(1 → 6)-d-glucan could improve the immune status by elevating T cell proliferation, phagocytic function of macrophage, CD3 <superscript>+</superscript> T cell level, CD4 <superscript>+</superscript> /CD8 <superscript>+</superscript> ratio, IL-6, IgG, IgM, TNF-α and hemolysin antibody levels. The immunostimulatory activities of α-(1 → 6)-d-glucan were similar to β-(1 → 3)-d-glucan, a clinical immunostimulatory drug. This work revealed that α-(1 → 6)-d-glucan was an important bioactive chemical for the immunostimulatory activity of banana. It could be used as a nutraceuticals candidate.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Cell Proliferation drug effects
Cytokines analysis
Enzyme-Linked Immunosorbent Assay
Glucans isolation & purification
Glucans pharmacology
Immunoglobulin G analysis
Immunoglobulin M analysis
Macrophages cytology
Macrophages drug effects
Macrophages metabolism
Male
Mice
Mice, Inbred BALB C
Phagocytosis drug effects
Polysaccharides isolation & purification
Polysaccharides pharmacology
T-Lymphocytes cytology
T-Lymphocytes drug effects
T-Lymphocytes metabolism
Glucans chemistry
Musa metabolism
Polysaccharides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-7072
- Volume :
- 277
- Database :
- MEDLINE
- Journal :
- Food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 30502171
- Full Text :
- https://doi.org/10.1016/j.foodchem.2018.10.043