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The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines.
- Source :
-
Investigational new drugs [Invest New Drugs] 2019 Oct; Vol. 37 (5), pp. 849-864. Date of Electronic Publication: 2018 Nov 29. - Publication Year :
- 2019
-
Abstract
- It has been shown previously that molecules built on benzanilide and thiobenzanilide scaffolds possess differential biological properties including selective anticancer activity. In our previous study, we examined the cytotoxic activity and mechanism of action of the thiobenzanilide derivative N,N'-(1,2-phenylene)bis3,4,5-trifluorobenzothioamide (63 T) as a potential chemotherapeutic compound in an experimental model employing A549 lung adenocarcinoma cells and CCD39Lu non-tumorigenic lung fibroblasts. Since the results suggested oxidative stress as a co-existing mechanism of the cytotoxic effect exerted by 63 T on tested cells, studies involving the analysis of reactive oxygen species (ROS) generation and markers of oxidative stress in cells incubated with 63 T were carried out. It may be concluded that the selective activity of 63 T against cancer cells shown in our experiments is caused, at least in part, by the response of the tested cells to 63 T mediated oxidative stress in both tested cell lines.
- Subjects :
- Adenocarcinoma of Lung drug therapy
Adenocarcinoma of Lung metabolism
Apoptosis
Cell Proliferation
Cells, Cultured
DNA Damage drug effects
Fibroblasts drug effects
Fibroblasts metabolism
Humans
Lipid Peroxidation drug effects
Lung drug effects
Lung metabolism
Lung Neoplasms drug therapy
Lung Neoplasms metabolism
Reactive Oxygen Species metabolism
Adenocarcinoma of Lung pathology
Antineoplastic Agents pharmacology
Benzene Derivatives pharmacology
Fibroblasts pathology
Lung pathology
Lung Neoplasms pathology
Oxidative Stress drug effects
Thioamides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-0646
- Volume :
- 37
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Investigational new drugs
- Publication Type :
- Academic Journal
- Accession number :
- 30498945
- Full Text :
- https://doi.org/10.1007/s10637-018-0704-8