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Chordoma of the corpus callosum: case report.

Authors :
Rinaldo L
Priemer DS
Vortmeyer AO
Cohen-Gadol AA
Brat DJ
Mahajan A
Giannini C
Burns TC
Source :
Journal of neurosurgery [J Neurosurg] 2018 Nov 16; Vol. 131 (5), pp. 1380-1386. Date of Electronic Publication: 2018 Nov 16 (Print Publication: 2019).
Publication Year :
2018

Abstract

Chordomas are neoplasms that typically arise from midline skeletal structures and rarely originate within the intradural compartment of the CNS. A chordoma arising from the corpus callosum has not been previously described. The authors report the surgical management of a chordoma originating within the splenium of the corpus callosum. To determine the incidence and distribution of intracranial intradural chordoma, a literature search for additional cases was performed. MEDLINE was searched using the MeSH keyword "chordoma," yielding 2010 articles. These articles were screened for cases of primary intradural chordoma rostral to the craniocervical junction, which led to the identification of 46 relevant articles. The authors report the case of a 69-year-old man who initially presented with nonspecific neurological symptoms including spatial disorientation and cognitive decline. These symptoms eventually prompted intracranial imaging, including MRI, which revealed a ring-enhancing, heterogeneous, cystic mass localized within the splenium of the corpus callosum and extending into the bilateral ventricles. The lesion was believed to represent a high-grade glioma and the patient underwent a left interhemispheric approach and subtotal resection. After pathologic evaluation confirmed a diagnosis of an anaplastic chordoma, the patient underwent further resection. A gross-total resection (GTR) was achieved with a transfalcine approach to the contralateral portion of the tumor. Postoperatively, the patient had a partial left homonymous quadrantanopsia, but was otherwise at his neurological baseline. Proton beam radiotherapy was performed to the resection cavity but diffuse intraventricular disease ensued. The results of a literature search suggest that a chordoma arising in the corpus callosum has not been previously described. The present case demonstrates that chordomas can occur in the corpus callosum, and illustrates the utility of a transfalcine approach for GTR of lesions in this location, as well as the need for improved strategies to prevent intraventricular dissemination.

Details

Language :
English
ISSN :
1933-0693
Volume :
131
Issue :
5
Database :
MEDLINE
Journal :
Journal of neurosurgery
Publication Type :
Academic Journal
Accession number :
30497142
Full Text :
https://doi.org/10.3171/2018.6.JNS181028