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Risk-Reducing Oophorectomy and Breast Cancer Risk Across the Spectrum of Familial Risk.
- Source :
-
Journal of the National Cancer Institute [J Natl Cancer Inst] 2019 Mar 01; Vol. 111 (3), pp. 331-334. - Publication Year :
- 2019
-
Abstract
- There remains debate about whether risk-reducing salpingo-oophorectomy (RRSO), which reduces ovarian cancer risk, also reduces breast cancer risk. We examined the association between RRSO and breast cancer risk using a prospective cohort of 17 917 women unaffected with breast cancer at baseline (7.2% known carriers of BRCA1 or BRCA2 mutations). During a median follow-up of 10.7 years, 1046 women were diagnosed with incident breast cancer. Modeling RRSO as a time-varying exposure, there was no association with breast cancer risk overall (hazard ratio [HR] = 1.04, 95% confidence interval [CI] = 0.87 to 1.24) or by tertiles of predicted absolute risk based on family history (HR = 0.68, 95% CI = 0.32 to 1.47, HR = 0.94, 95% CI = 0.70 to 1.26, and HR = 1.10, 95% CI = 0.88 to 1.39, for lowest, middle, and highest tertile of risk, respectively) or for BRCA1 and BRCA2 mutation carriers when examined separately. There was also no association after accounting for hormone therapy use after RRSO. These findings suggest that RRSO should not be considered efficacious for reducing breast cancer risk.<br /> (© The Author(s) 2018. Published by Oxford University Press.)
- Subjects :
- Adult
BRCA1 Protein genetics
BRCA2 Protein genetics
Breast Neoplasms etiology
Female
Follow-Up Studies
Humans
Middle Aged
Mutation
Ovarian Neoplasms genetics
Prognosis
Prospective Studies
Breast Neoplasms prevention & control
Genetic Predisposition to Disease
Ovarian Neoplasms surgery
Ovariectomy methods
Risk Reduction Behavior
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2105
- Volume :
- 111
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of the National Cancer Institute
- Publication Type :
- Academic Journal
- Accession number :
- 30496449
- Full Text :
- https://doi.org/10.1093/jnci/djy182