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L-Carnitine Supplementation Increases Trimethylamine-N-Oxide but not Markers of Atherosclerosis in Healthy Aged Women.
- Source :
-
Annals of nutrition & metabolism [Ann Nutr Metab] 2019; Vol. 74 (1), pp. 11-17. Date of Electronic Publication: 2018 Nov 28. - Publication Year :
- 2019
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Abstract
- Background: L-carnitine can be metabolized to trimethylamine N-oxide (TMAO), a molecule that promotes atherogenesis through its interaction with macrophages and lipid metabolism.<br />Objective: The aim of the present study was to assess whether L-carnitine supplementation may promote changes in selected serum biomarkers of atherosclerosis.<br />Methods: Before the start, in the mid-point and after completing the 24-weeks supplementation protocol, fasting blood samples were taken from the antecubital vein. Plasma free L-carnitine and TMAO were determined by the UPLC/MS/MS method. Serum proteins were determined by the enzyme immunoassay method using commercially available kits. Total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and triglycerides have been determined using standard automatic analyzer.<br />Results: L-carnitine supplementation elevated fasting plasma carnitine in the mid-point of our study and it remained increased until the end of supplementation period. Moreover, it induced tenfold increase in plasma TMAO concentration but did not affect serum C-reactive protein, interleukin-6, tumour necrosis factor-α, L-selectin, P-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1 or lipid profile markers.<br />Conclusion: We demonstrated that -although oral L-carnitine supplementation significantly -increased plasma TMAO concentration, no lipid profile changes or other markers of adverse cardiovascular events were detected in healthy aged women over the period of 24 weeks.<br /> (© 2018 S. Karger AG, Basel.)
Details
- Language :
- English
- ISSN :
- 1421-9697
- Volume :
- 74
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of nutrition & metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 30485835
- Full Text :
- https://doi.org/10.1159/000495037