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Peptides/Proteins Encoded by Non-coding RNA: A Novel Resource Bank for Drug Targets and Biomarkers.
- Source :
-
Frontiers in pharmacology [Front Pharmacol] 2018 Nov 13; Vol. 9, pp. 1295. Date of Electronic Publication: 2018 Nov 13 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Non-coding RNAs (ncRNAs) are defined as RNA molecules that do not encode proteins, but recent evidence has proven that peptides/proteins encoded by ncRNAs do indeed exist and usually contain less than 100 amino acids. These peptides/proteins play an important role in regulating tumor energy metabolism, epithelial to mesenchymal transition of cancer cells, the stability of the c-Myc oncoprotein, and the ubiquitination and degradation of proliferating cell nuclear antigen (PCNA). These peptides/proteins represent promising drug targets for fighting against tumor growth or biomarkers for predicting the prognosis of cancer patients. In this review, we summarize the characteristics of peptides/proteins that have recently been identified as putative ncRNA translation products and their outlook for small molecule peptide drugs, drug targets, and biomarkers.
Details
- Language :
- English
- ISSN :
- 1663-9812
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Frontiers in pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 30483132
- Full Text :
- https://doi.org/10.3389/fphar.2018.01295