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A Concerted Synchronous [2 + 2] Cycloreversion Repair Catalyzed by Two Electrons.
- Source :
-
The journal of physical chemistry letters [J Phys Chem Lett] 2018 Dec 20; Vol. 9 (24), pp. 6973-6977. Date of Electronic Publication: 2018 Dec 03. - Publication Year :
- 2018
-
Abstract
- The current understanding of photoenzyme-catalyzed [2 + 2] cycloreversion repair of cyclobutane pyrimidine dimer (CPD) is that a photogenerated electron from the photolyase enzyme catalyzes the repair. This one-electron catalyzed repair is a sequential two-bond breaking cycloreversion of the cyclobutane center and involves a negative ion radical as an intermediate. Here, by resonantly capturing two exogenous low-energy electrons into the molecular field of a CPD, we show that the concerted synchronous two-bond breaking reaction, which is intermediate-free, and hence a safe repair, is feasible through two-electron catalysis.
Details
- Language :
- English
- ISSN :
- 1948-7185
- Volume :
- 9
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- The journal of physical chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 30481035
- Full Text :
- https://doi.org/10.1021/acs.jpclett.8b03256