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Oxidative Damages to Eye Stem Cells, in Response to, Bright and Ultraviolet Light, Their Associated Mechanisms, and Salvage Pathways.
- Source :
-
Molecular biotechnology [Mol Biotechnol] 2019 Feb; Vol. 61 (2), pp. 145-152. - Publication Year :
- 2019
-
Abstract
- The surface of the eye is continuously exposed to the harshness of the external environment. As a homeostatic mechanism for replenishing the worn off cells of the ocular surface, a balance is maintained via the role of ocular stem cells. However, under extreme conditions of harshness like exposure to bright and ultraviolet light, the ocular stem cells are unable to do the repair mechanisms resulting in severe impairment of vision and disturbances in the eye. This work reappraises the recent understandings of mechanisms of oxidative damages caused to the ocular stem cells by UV/bright light and their probable mitigation.
- Subjects :
- Animals
Apoptosis radiation effects
Epithelial Cells cytology
Epithelial Cells metabolism
Epithelial Cells radiation effects
Eye cytology
Humans
Oxidative Stress radiation effects
Stem Cell Transplantation
Stem Cells cytology
Stem Cells metabolism
Eye radiation effects
Oxidative Stress physiology
Signal Transduction radiation effects
Stem Cells radiation effects
Ultraviolet Rays adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0305
- Volume :
- 61
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Molecular biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 30474787
- Full Text :
- https://doi.org/10.1007/s12033-018-0136-x