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Spotlight on Bortezomib: potential in the treatment of hepatocellular carcinoma.
- Source :
-
Expert opinion on investigational drugs [Expert Opin Investig Drugs] 2019 Jan; Vol. 28 (1), pp. 7-18. Date of Electronic Publication: 2018 Nov 30. - Publication Year :
- 2019
-
Abstract
- Introduction: This study reviews the evidence for the use of Bortezomib (BZB), a first-in-class proteasome inhibitor in advanced Hepatocellular carcinoma (HCC). This review aims to delineate the role of BZB within the management of non-surgical and metastatic HCC, either as an alternative or as an adjunct to the current treatment paradigm.<br />Areas Covered: In addition to BZB pharmacology and mechanism of action, safety and tolerance profiles of the drug obtained from clinical trials are explored. The utility of BZB as a therapeutic agent either alone or in combination with other therapies against HCC, including its application in both preclinical and clinical settings has been reviewed. In particular, we highlight the importance of preclinical evaluation of BZB as a combinatorial agent in synergism with other therapies for the use in the management of HCC.<br />Expert Opinion: There has been much interest surrounding the use of BZB, a first-in-class proteasome inhibitor for HCC therapy. The discernment of outcomes of BZB clinical trials for HCC need to take into consideration the disease-specific factors that can affect survival outcomes including patient selection and aetiological differences. Further preclinical testing of BZB in combination with other therapeutic modalities can be important for eliciting enhanced anti-HCC effects.
- Subjects :
- Animals
Antineoplastic Agents administration & dosage
Antineoplastic Agents adverse effects
Antineoplastic Agents pharmacology
Bortezomib adverse effects
Bortezomib pharmacology
Carcinoma, Hepatocellular pathology
Humans
Liver Neoplasms pathology
Neoplasm Metastasis
Patient Selection
Proteasome Inhibitors administration & dosage
Proteasome Inhibitors adverse effects
Proteasome Inhibitors pharmacology
Survival
Bortezomib administration & dosage
Carcinoma, Hepatocellular drug therapy
Liver Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1744-7658
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Expert opinion on investigational drugs
- Publication Type :
- Academic Journal
- Accession number :
- 30474444
- Full Text :
- https://doi.org/10.1080/13543784.2019.1551359