Six New Phragmalin Limonoids from the Stems of Chukrasia tabularis A. Juss.

Six new phragmalin limonoids, named moluccensin Z1 ( 1 ), moluccensin Z2 ( 2 ), carapanolide Y ( 3 ), tabulalin N ( 4 ), chukvelutilide A1 ( 5 ), and velutinasin J ( 6 ), as well as two known compounds, chukvelutilide A ( 7 ) and velutinasin D ( 8 ) were isolated from the stems of Chukrasia tabularis A. Juss. The structures of the new compounds 1 ⁻ 6 were confirmed by spectroscopic methods, including IR and HRESIMS, as well as 1D and 2D NMR, and by comparisons with the data of known analogues. All compounds were tested for α-glucosidase and acetylcholinesterase inhibitory activities. However, none of the compounds was active against α-glucosidase and acetylcholinesterase in vitro.