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Sexually Acquired Hepatitis C Infection in HIV-Uninfected Men Who Have Sex With Men Using Preexposure Prophylaxis Against HIV.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2019 Apr 16; Vol. 219 (9), pp. 1373-1376. - Publication Year :
- 2019
-
Abstract
- Sexually acquired hepatitis C virus (HCV) infections among human immunodeficiency virus (HIV)-uninfected men who have sex with men (MSM) have been rare. With the introduction of preexposure prophylaxis (PrEP) against HIV, we hypothesized that these infections would increase. Between 2013 and 2018, we diagnosed 15 likely sexually acquired HCV infections among 14 MSM using PrEP. Most (87%) were asymptomatic, detected by routine alanine transaminase (ALT) or HCV monitoring. Half reported increasing sex partners and drug use after starting PrEP; 5 reported injection of methamphetamine. Interventions are needed to prevent sexually acquired HCV infections by MSM using PrEP. Centers for Disease Control and Prevention guidelines for monitoring during PrEP should include regular ALT and HCV testing.<br /> (© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
- Subjects :
- Adult
Genotype
Hepacivirus genetics
Hepatitis C virology
Humans
Male
Pre-Exposure Prophylaxis
Sexual Behavior
Sexual and Gender Minorities
Sexually Transmitted Diseases, Viral virology
HIV Infections prevention & control
HIV Seronegativity
Hepatitis C diagnosis
Sexually Transmitted Diseases, Viral diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 219
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 30462305
- Full Text :
- https://doi.org/10.1093/infdis/jiy670