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Sex difference in the association of body mass index and BDNF levels in Chinese patients with chronic schizophrenia.
- Source :
-
Psychopharmacology [Psychopharmacology (Berl)] 2019 Feb; Vol. 236 (2), pp. 753-762. Date of Electronic Publication: 2018 Nov 19. - Publication Year :
- 2019
-
Abstract
- Rationale and Objective: Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex differences in the relationship between serum BDNF levels and obesity in patients with chronic schizophrenia.<br />Methods: We recruited 132 Chinese patients with chronic schizophrenia (98 males and 34 females) and compared sex differences in the body mass index (BMI), obesity, serum BDNF levels, and their associations. Psychopathology symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). A regression model with various demographic and clinical variables was applied to predict the serum levels of BDNF.<br />Results: Female patients had a higher rate of obesity and higher BMI, but lower BDNF levels than male schizophrenia patients. A significantly negative correlation was observed between BMI and BDNF levels only in female patients but not in male patients. The multiple regression model with demographic and clinical variables significantly predicted BDNF levels only in female patients, with a medium size effect. And only in female patients, BMI made a significant contribution to this prediction.<br />Conclusion: Our results indicate significant sex differences in the obesity, BMI, BDNF levels, and their association in chronic patients with schizophrenia, showing a significant inverse correlation between BMI and BDNF levels only in female patients. Thus, sex needs to be considered when assessing the relationship between BDNF and metabolic syndromes in schizophrenia.
- Subjects :
- Adult
Aged
Antipsychotic Agents adverse effects
Antipsychotic Agents therapeutic use
Biomarkers blood
China epidemiology
Female
Humans
Male
Metabolic Syndrome blood
Metabolic Syndrome chemically induced
Metabolic Syndrome epidemiology
Middle Aged
Obesity blood
Obesity chemically induced
Obesity epidemiology
Psychiatric Status Rating Scales
Random Allocation
Schizophrenia drug therapy
Body Mass Index
Brain-Derived Neurotrophic Factor blood
Schizophrenia blood
Schizophrenia epidemiology
Sex Characteristics
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2072
- Volume :
- 236
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 30456540
- Full Text :
- https://doi.org/10.1007/s00213-018-5107-1