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Clinical spectrum of Lyme disease.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2019 Feb; Vol. 38 (2), pp. 201-208. Date of Electronic Publication: 2018 Nov 19. - Publication Year :
- 2019
-
Abstract
- Lyme disease (borreliosis) is one of the most common vector-borne diseases worldwide. Its incidence and geographic expansion has been steadily increasing in the last decades. Lyme disease is caused by Borrelia burgdorferi sensu lato, a heterogeneous group of which three genospecies have been systematically associated to Lyme disease: B. burgdorferi sensu stricto Borrelia afzelii and Borrelia garinii. Geographical distribution and clinical manifestations vary according to the species involved. Lyme disease clinical manifestations may be divided into three stages. Early localized stage is characterized by erythema migrans in the tick bite site. Early disseminated stage may present multiple erythema migrans lesions, borrelial lymphocytoma, lyme neuroborreliosis, carditis, or arthritis. The late disseminated stage manifests with acordermatitis chronica atrophicans, lyme arthritis, and neurological symptoms. Diagnosis is challenging due to the varied clinical manifestations it may present and usually involves a two-step serological approach. In the current review, we present a thorough revision of the clinical manifestations Lyme disease may present. Additionally, history, microbiology, diagnosis, post-treatment Lyme disease syndrome, treatment, and prognosis are discussed.
- Subjects :
- Animals
Anti-Bacterial Agents therapeutic use
Borrelia burgdorferi Group classification
Borrelia burgdorferi Group drug effects
Clinical Laboratory Techniques
Humans
Ixodes classification
Ixodes microbiology
Prognosis
Treatment Outcome
Borrelia burgdorferi Group physiology
Lyme Disease diagnosis
Lyme Disease drug therapy
Lyme Disease pathology
Lyme Disease physiopathology
Skin Diseases, Bacterial diagnosis
Skin Diseases, Bacterial drug therapy
Skin Diseases, Bacterial pathology
Skin Diseases, Bacterial physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1435-4373
- Volume :
- 38
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 30456435
- Full Text :
- https://doi.org/10.1007/s10096-018-3417-1