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Minocycline prevents peroxidative permeabilization of cardiolipin-containing bilayer lipid membranes mediated by cytochrome c.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2018 Dec 09; Vol. 507 (1-4), pp. 510-513. Date of Electronic Publication: 2018 Nov 16. - Publication Year :
- 2018
-
Abstract
- Peroxidase activity of cytochrome c stimulated by interaction of the protein with cardiolipin is considered to be involved in the induction of mitochondrial apoptosis associated with cytochrome c release from mitochondria. In model systems, this activity has been previously shown to cause permeabilization of cardiolipin-containing membranes. Here, we found that the antibiotic minocycline, known to have neuroprotective properties, inhibited both the binding of cyt c to cardiolipin-containing membranes and the cyt c/H <subscript>2</subscript> O <subscript>2</subscript> -induced liposome permeabilization. The results could be relevant to inhibition of cyt c release from mitochondria exerted by minocycline.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 507
- Issue :
- 1-4
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 30454899
- Full Text :
- https://doi.org/10.1016/j.bbrc.2018.11.078