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Antidepressant agomelatine attenuates behavioral deficits and concomitant pathology observed in streptozotocin-induced model of Alzheimer's disease in male rats.
- Source :
-
Hormones and behavior [Horm Behav] 2019 Jan; Vol. 107, pp. 11-19. Date of Electronic Publication: 2018 Nov 22. - Publication Year :
- 2019
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Abstract
- Experimental findings suggest that the melatonin system has a beneficial role in models of Alzheimer's disease (ADs). The aim of the present study was to explore whether the atypical antidepressant agomelatine (Ago), which is a melatonin MT <subscript>1</subscript> and MT <subscript>2</subscript> agonist and 5-HT <subscript>2C</subscript> antagonist, is effective against behavioral, biochemical and histological impairments in streptozotocin (STZ)-induced model of ADs in male rats. Male Sprague Dawley rats were treated intraperitoneally (i.p.) with Ago (40 mg/kg) for 30 days starting three months following the intracerebroventricular (icv) injection of STZ. Chronic Ago treatment reduced anxiety-like behavior of STZ-treated rats in the elevated plus maze, increased the preference to saccharine and corrected the spatial memory impairment in the eight-arm radial arm maze test. This melatonin analogue restored STZ-induced biochemical changes, including an increase of beta amyloid (Aβ) protein, and signal markers of inflammation (TNF-alpha and IL-1 beta). Ago exerted partial neuroprotection, specifically in the temporal CA3b subfield of the dorsal hippocampus and temporal piriform cortex. The ability of Ago to alleviate behavioral symptoms and concomitant neuropathological events observed in a model of sporadic ADs suggests that this melatonin alternative can be considered a promising adjuvant in this disease.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Alzheimer Disease pathology
Alzheimer Disease physiopathology
Animals
Anxiety metabolism
Anxiety pathology
Anxiety physiopathology
Disease Models, Animal
Exploratory Behavior drug effects
Hippocampus drug effects
Male
Maze Learning drug effects
Melatonin metabolism
Memory Disorders chemically induced
Memory Disorders metabolism
Memory Disorders pathology
Rats
Rats, Sprague-Dawley
Acetamides pharmacology
Alzheimer Disease chemically induced
Antidepressive Agents pharmacology
Behavior, Animal drug effects
Streptozocin
Subjects
Details
- Language :
- English
- ISSN :
- 1095-6867
- Volume :
- 107
- Database :
- MEDLINE
- Journal :
- Hormones and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 30452900
- Full Text :
- https://doi.org/10.1016/j.yhbeh.2018.11.007