Back to Search
Start Over
High-dose combination alkylating agent therapy with autologous bone marrow rescue for refractory solid tumors.
- Source :
-
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 1988 Aug; Vol. 6 (8), pp. 1314-20. - Publication Year :
- 1988
-
Abstract
- Twenty-six adults, ages 27 to 60, with refractory metastatic solid tumors were treated with high-dose cyclophosphamide (Cy) + carmustine (BCNU) at one of three escalating dose schedules followed by autologous bone marrow transplantation (ABMT). Toxicity was severe and dose-related, with the maximum tolerated dose for the combination determined to be Cy 160 mg/kg and BCNU 900 mg/m2. Median time to WBC recovery (greater than or equal to 1,000/microL) was 13 days post-ABMT (range, nine to 22 days) and to a platelet count of greater than or equal to 50,000/microL, 22 days (range, 13 to 83 days). Sixteen of 20 evaluable patients (80%) responded to therapy with at least 50% reduction in measurable tumor, and three patients achieved complete remission (CR). Responders included eight of nine evaluable patients with breast carcinoma, two of five with melanoma, two of two with sarcoma, and four of four with colon carcinoma. Response durations were short (median, 4 months), even for complete responders, and relapses generally occurred at sites of previous metastases. In order for this approach to have a more significant impact on overall survival, it may need to be applied earlier in the natural history of the malignancy.
- Subjects :
- Adult
Antineoplastic Combined Chemotherapy Protocols adverse effects
Bacterial Infections etiology
Carmustine administration & dosage
Carmustine adverse effects
Combined Modality Therapy
Cyclophosphamide administration & dosage
Cyclophosphamide adverse effects
Drug Evaluation
Female
Humans
Male
Middle Aged
Neoplasms drug therapy
Neoplasms mortality
Remission Induction
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Bone Marrow Transplantation
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0732-183X
- Volume :
- 6
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 3045266
- Full Text :
- https://doi.org/10.1200/JCO.1988.6.8.1314