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Systemic Sarcoidosis Presenting with Renal Involvement Caused by Various Sarcoidosis-associated Pathophysiological Conditions.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2019 Mar 01; Vol. 58 (5), pp. 679-684. Date of Electronic Publication: 2018 Nov 19. - Publication Year :
- 2019
-
Abstract
- A 61-year-old man was diagnosed with sarcoidosis involving the lungs, eyes, parotid gland and extrathoracic lymph nodes complicated by chronic kidney injury and hypercalcemia. Kidney biopsy showed non-specific interstitial nephritis and nephrosclerosis. However, immunohistochemical staining of cell surface markers revealed a multinucleated giant macrophage surrounded by T-cells, suggesting granulomatous interstitial nephritis. Corticosteroid improved the kidney function, and reduced the serum levels of calcium and angiotensin-converting enzyme. Sarcoid nephropathy may be caused by the combination of several sarcoidosis-associated pathophysiological conditions and a comprehensive kidney examination should be performed to assess the type of injury when determining a treatment strategy.
- Subjects :
- Biomarkers blood
Biopsy
Calcium blood
Glucocorticoids therapeutic use
Humans
Hypercalcemia etiology
Kidney pathology
Male
Middle Aged
Nephritis, Interstitial blood
Nephritis, Interstitial drug therapy
Nephritis, Interstitial pathology
Nephrosclerosis blood
Nephrosclerosis etiology
Nephrosclerosis pathology
Peptidyl-Dipeptidase A blood
Radionuclide Imaging
Sarcoidosis blood
Sarcoidosis drug therapy
Sarcoidosis pathology
Nephritis, Interstitial etiology
Sarcoidosis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 58
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 30449791
- Full Text :
- https://doi.org/10.2169/internalmedicine.1558-18