Bioactive xanthoquinodins and epipolythiodioxopiperazines from Chaetomium globosum 7s-1, an endophytic fungus isolated from Rhapis cochinchinensis (Lour.) Mart.

A new xanthoquinodin B9 ( 1 ), together with two known xanthoquinodins, xanthoquinodin A1 ( 2 ) and xanthoquinodin A3 ( 3 ), three epipolythiodioxopiperazines, chetomin ( 4 ), chaetocochin C ( 5 ) and dethio-tetra(methylthio)chetomin ( 6 ), and four other compounds, chrysophanol ( 7 ), emodin ( 8 ), alatinone ( 9 ), and ergosterol ( 10 ) were isolated from the endophytic fungus Chaetomium globosum 7s-1, isolated from Rhapis cochinchinensis (Lour.) Mart. All isolated structures were established based on their spectroscopic data analyses. Compounds 1-6 showed antibacterial activity against Gram positive bacteria with MICs ranging from 0.02 pM to 10.81 µM. Compounds 1-6 also exhibited cytotoxicity against KB, MCF-7 and NCI-H187 cancer cell lines (IC ₅₀ 0.04-18.40 µM). However, they were cytotoxic towards a normal cell line ( Vero cell) with IC ₅₀ values ranging from 0.04 to 3.86 µM.