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Anti- β -amyloid aggregation activity of enantiomeric furolactone-type lignans from Archidendron clypearia (Jack) I.C.N.
- Source :
-
Natural product research [Nat Prod Res] 2020 Feb; Vol. 34 (4), pp. 456-463. Date of Electronic Publication: 2018 Nov 16. - Publication Year :
- 2020
-
Abstract
- The phytochemical investigation on the twigs and leaves of Archidendron clypearia (Jack) I.C.N. led to the isolation of three pairs of furolactone-type lignans enantiomers, including a pair of new compounds (1 R ,5 S ,6 S )-Kachiranol ( 1a ) and (1 S ,5 R ,6 R )-Kachiranol ( 1b ) and four known compounds ( 2a / 2b and 3a / 3b ). Separation of the furolactone-type lignans enantiomeric mixtures was achieved using chiral HPLC for the first time. Their structures were determined by spectroscopic analysis and comparison between the experimental and calculated electronic circular dichroism (ECD) spectra. All optical pure compounds were evaluated for their inhibitory effects on β -amyloid aggregation by ThT assay. Among them, the inhibitory activity of the compound 1b (71.1%) was higher than the positive control (61.0%) and other compounds. In addition, molecular dynamics and molecular docking were employed to explore the binding relationship between the ligand and the receptor.
- Subjects :
- Amyloid beta-Peptides drug effects
Circular Dichroism
Lignans isolation & purification
Lignans pharmacology
Molecular Docking Simulation
Molecular Structure
Phytochemicals pharmacology
Phytochemicals therapeutic use
Protein Aggregation, Pathological prevention & control
Stereoisomerism
Fabaceae chemistry
Lignans chemistry
Phytochemicals analysis
Protein Aggregation, Pathological drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 34
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 30445834
- Full Text :
- https://doi.org/10.1080/14786419.2018.1488705