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Metabolomic Profiling of Infants With Recurrent Wheezing After Bronchiolitis.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2019 Apr 08; Vol. 219 (8), pp. 1216-1223. - Publication Year :
- 2019
-
Abstract
- Background: Bronchiolitis is associated with a greater risk of developing recurrent wheezing, but with currently available tools, it is impossible to know which infants with bronchiolitis will develop this condition. This preliminary prospective study aimed to assess whether urine metabolomic analysis can be used to identify children with bronchiolitis who are at risk of developing recurrent wheezing.<br />Methods: Fifty-two infants <1 year old treated in the emergency department at University Hospital of Padova for acute bronchiolitis were enrolled (77% tested positive for respiratory syncytial virus [RSV]). Follow-up visits were conducted for 2 years after the episode of bronchiolitis. Untargeted metabolomic analyses based on mass spectrometry were performed on urine samples collected from infants with acute bronchiolitis. Data modeling was based on univariate and multivariate data analyses.<br />Results: We distinguished children with and those without postbronchiolitis recurrent wheeze, defined as ≥3 episodes of physician-diagnosed wheezing. Pathway overrepresentation analysis pointed to a major involvement of the citric acid cycle (P < .001) and some amino acids (lysine, cysteine, and methionine; P ≤ .015) in differentiating between these 2 groups of children.<br />Conclusion: This is the first study showing that metabolomic profiling of urine specimens from infants with bronchiolitis can be used to identify children at increased risk of developing recurrent wheezing.<br /> (© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
- Subjects :
- Bronchiolitis complications
Bronchiolitis urine
Case-Control Studies
Citric Acid urine
Citric Acid Cycle
Cysteine metabolism
Cysteine urine
Female
Humans
Infant
Infant, Newborn
Lysine metabolism
Lysine urine
Male
Metabolic Networks and Pathways
Methionine metabolism
Methionine urine
Prospective Studies
Recurrence
Risk Factors
Bronchiolitis metabolism
Metabolomics
Respiratory Sounds etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 219
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 30445537
- Full Text :
- https://doi.org/10.1093/infdis/jiy659