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Population-based birth defects data in the United States, 2011-2015: A focus on eye and ear defects.
- Source :
-
Birth defects research [Birth Defects Res] 2018 Nov 15; Vol. 110 (19), pp. 1478-1486. Date of Electronic Publication: 2018 Nov 16. - Publication Year :
- 2018
-
Abstract
- Background/objectives: In this data brief, we examine major eye and ear anomalies (anophthalmia/microphthalmia, anotia/microtia, and congenital cataract) for a recent 5-year birth cohort using data from 30 population-based birth defects surveillance programs in the United States.<br />Methods: As a special call for data for the 2018 NBDPN Annual Report, state programs reported expanded data on eye/ear anomalies for birth years 2011-2015. We calculated the combined overall prevalence (per 10,000 live births) and 95% confidence intervals (CI), for the three anomalies as well as by maternal age, maternal race/ethnicity, infant sex, laterality, presence/absence of other major birth defects, and case ascertainment methodology utilized by the program (active vs. passive).<br />Results: The overall prevalence estimate (per 10,000 live births) was 1.5 (95% CI: 1.4-1.5) for anophthalmia/microphthalmia, 1.5 (95% CI: 1.4-1.6) for congenital cataract, and 1.8 (95% CI: 1.7-1.8) for anotia/microtia. Congenital cataract prevalence varied little by maternal race/ethnicity, infant sex, or case ascertainment methodology; prevalence differences were more apparent across strata for anophthalmia/microphthalmia and anotia/microtia. Prevalence among active vs. passive ascertainment programs was 50% higher for anophthalmia/microphthalmia (1.9 vs. 1.2) and two-fold higher for anotia/microtia (2.6 vs. 1.2). Anophthalmia/microphthalmia was more likely than other conditions to co-occur with other birth defects. All conditions were more frequent among older mothers (40+ years).<br />Conclusions: This data brief provides recent prevalence estimates for anophthalmia/microphthalmia, congenital cataract, and anotia/microtia that address a data gap by examining pooled data from 30 population-based surveillance systems, covering a five-year birth cohort of about 12.4 million births.<br /> (© 2018 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Case-Control Studies
Cataract epidemiology
Congenital Abnormalities epidemiology
Ear abnormalities
Eye Abnormalities
Female
Humans
Infant
Infant, Newborn
Logistic Models
Male
Maternal Age
Mothers
Odds Ratio
Population Surveillance methods
Pregnancy
Prevalence
Registries
Risk Factors
United States
Anophthalmos epidemiology
Congenital Microtia epidemiology
Microphthalmos epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2472-1727
- Volume :
- 110
- Issue :
- 19
- Database :
- MEDLINE
- Journal :
- Birth defects research
- Publication Type :
- Academic Journal
- Accession number :
- 30444307
- Full Text :
- https://doi.org/10.1002/bdr2.1413