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Contrast-Enhanced Ultrasound to Quantifyc Perfusion in a Machine-Perfused Pig Liver.

Authors :
Chen M
Li Q
Karimian N
Yeh H
Duan Y
Fontan F
Aburawi MM
Anthony BW
Uygun K
Samir AE
Source :
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2018 Jul; Vol. 2018, pp. 3128-3131.
Publication Year :
2018

Abstract

This paper introduces a non-invasive, contrastenhanced ultrasound (CEUS) infusion method to quantify the health of viable donor livers. The method uses the infusion of microbubbles and their destruction and subsequent replenishment to measure the perfusion rate in the liver microvasculature. The proposed method improves on the previous parameter extraction approaches applied to the flashreplenishment technique by addressing the effects of the microbubble mixing within the perfusate bath and destruction rate. By doing so, the tissue perfusion rate can be extracted from the data even though the microbubble concentration is not constant throughout image acquisition. The measured changes in the tissue perfusion rate showed that CEUS infusion is a viable biomarker for assessing liver health.

Details

Language :
English
ISSN :
2694-0604
Volume :
2018
Database :
MEDLINE
Journal :
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Publication Type :
Academic Journal
Accession number :
30441057
Full Text :
https://doi.org/10.1109/EMBC.2018.8512893