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Assessment of herd effects among women and heterosexual men after girls-only HPV16/18 vaccination in the Netherlands: A repeated cross-sectional study.
- Source :
-
International journal of cancer [Int J Cancer] 2019 Jun 01; Vol. 144 (11), pp. 2718-2727. Date of Electronic Publication: 2018 Dec 21. - Publication Year :
- 2019
-
Abstract
- Data on the impact of human papillomavirus (HPV) vaccination on the population HPV prevalence are largely obtained from women. We assessed the impact of the girls-only HPV16/18 vaccination program in the Netherlands that started in 2009, on trends in HPV prevalence among women and heterosexual men, using data from the PASSYON study. In this cross-sectional study, the HPV prevalence among 16- to 24-year-old visitors to sexually transmitted infection clinics was assessed in 2009, 2011, 2013, and 2015. We compared the genital postvaccination HPV prevalence with the prevaccination prevalence (2009) using Poisson GEE models. In total, we included 4,996 women and 1,901 heterosexual men. The percentage of women who reported to be vaccinated increased from 2.3% in 2009 to 37% in 2015. Among all women, the HPV16/18 prevalence decreased from 23% prevaccination to 15% in 2015 (adjusted prevalence ratio [aPR] 0.62, p <subscript>trend</subscript> < 0.01). Among heterosexual men, the HPV16/18 prevalence decreased from 17% prevaccination to 11% in 2015 (aPR 0.52, p <subscript>trend</subscript> < 0.01). Of the heterosexual men with a steady partner, HPV16/18 prevalence was lower among those whose steady partner had been vaccine-eligible in the national immunization program (aPR 0.13). Among unvaccinated women, the HPV16/18 prevalence in 2015 was not different from prevaccination. The decreasing HPV16/18 prevalence among heterosexual men and the reduced HPV16/18 prevalence among heterosexual men with a vaccine-eligible steady partner strongly suggests herd protection from girls-only vaccination. Absence of notable herd effects among unvaccinated women 6 years postvaccination may be due to the moderate vaccine uptake among girls in the Netherlands.<br /> (© 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)
- Subjects :
- Adolescent
Adult
Cross-Sectional Studies
Female
Human papillomavirus 16 immunology
Human papillomavirus 18 immunology
Humans
Male
Mass Vaccination methods
Netherlands epidemiology
Papillomavirus Infections immunology
Papillomavirus Infections prevention & control
Papillomavirus Infections virology
Papillomavirus Vaccines immunology
Prevalence
Program Evaluation
Sexually Transmitted Diseases immunology
Sexually Transmitted Diseases prevention & control
Sexually Transmitted Diseases virology
Uterine Cervical Neoplasms immunology
Uterine Cervical Neoplasms prevention & control
Uterine Cervical Neoplasms virology
Young Adult
Mass Vaccination statistics & numerical data
Outcome Assessment, Health Care statistics & numerical data
Papillomavirus Infections epidemiology
Papillomavirus Vaccines administration & dosage
Sexually Transmitted Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0215
- Volume :
- 144
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30426502
- Full Text :
- https://doi.org/10.1002/ijc.31989