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Polygenic Risk Scores Derived From a Tourette Syndrome Genome-wide Association Study Predict Presence of Tics in the Avon Longitudinal Study of Parents and Children Cohort.
- Source :
-
Biological psychiatry [Biol Psychiatry] 2019 Feb 15; Vol. 85 (4), pp. 298-304. Date of Electronic Publication: 2018 Sep 29. - Publication Year :
- 2019
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Abstract
- Background: Tourette syndrome (TS) has a well-established genetic background, but its genetic architecture remains largely unknown. The authors investigated the role of polygenic risk scores (PRSs) derived from a TS genome-wide association study in relation to the occurrence of tics and associated traits in a general population cohort.<br />Methods: Using the most recent TS genome-wide association study (n = 4819 cases; n = 9488 controls) as the discovery sample, PRSs were calculated in Avon Longitudinal Study of Parents and Children participants (n = 8941). Regression analyses were used to assess whether PRS predicted the presence and chronicity of tics, and symptom severity of obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, and autism spectrum disorder in Avon Longitudinal Study of Parents and Children participants.<br />Results: Following correction for multiple testing, the PRS significantly predicted the presence (R <superscript>2</superscript>  = .48%, p empirical = .01, Q = .04) but not the chronicity (R <superscript>2</superscript>  = .16%, p empirical = .07, Q = .14) of tics in the Avon Longitudinal Study of Parents and Children cohort; it did not predict the severity of obsessive-compulsive disorder (R <superscript>2</superscript>  = .11%, p empirical = .11, Q = .15), attention-deficit/hyperactivity disorder (R <superscript>2</superscript>  = .09%, p empirical = .19, Q = .21), or autism spectrum disorder (R <superscript>2</superscript>  = .12%, p empirical = .09, Q = .14).<br />Conclusions: The authors found a significant polygenic component of tics occurring in a general population cohort based on PRS derived from a genome-wide association study of individuals with a TS diagnosis. This finding supports the notion that tics along a spectrum from nonclinical to clinical symptom levels share a similar genetic background.<br /> (Copyright © 2018 Society of Biological Psychiatry. All rights reserved.)
- Subjects :
- Adolescent
Attention Deficit Disorder with Hyperactivity genetics
Autism Spectrum Disorder genetics
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Female
Genotype
Humans
Infant
Male
Obsessive-Compulsive Disorder genetics
Phenotype
Severity of Illness Index
Genome-Wide Association Study
Multifactorial Inheritance genetics
Tic Disorders genetics
Tourette Syndrome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2402
- Volume :
- 85
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 30424865
- Full Text :
- https://doi.org/10.1016/j.biopsych.2018.09.011