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Correlations between serum concentration of three bone-derived factors and obesity and visceral fat accumulation in a cohort of middle aged men and women.
- Source :
-
Cardiovascular diabetology [Cardiovasc Diabetol] 2018 Nov 13; Vol. 17 (1), pp. 143. Date of Electronic Publication: 2018 Nov 13. - Publication Year :
- 2018
-
Abstract
- Background: The aim of this study was to investigate the interrelationships between three bone-derived factors [serum osteocalcin (OCN), fibroblast growth factor (FGF) 23, and neutrophil gelatinase-associated lipocalin (NGAL) levels] and body fat content and distribution, in order to reveal the potential endocrine function of bone in the development of obesity.<br />Methods: We recruited 1179 people (aged 59.5 ± 6.2 years) from communities in Shanghai. Serum OCN levels were determined using an electrochemiluminescence immunoassay. Serum FGF23 and NGAL levels were determined using a sandwich enzyme-linked immunosorbent assay. The abdominal fat distribution, including visceral fat area (VFA), was assessed by magnetic resonance imaging. Visceral obesity was defined as a VFA ≥ 80 cm <superscript>2</superscript> .<br />Results: Serum OCN levels were inversely correlated with body fat parameters, while FGF23 and NGAL were positively correlated (P < 0.05). After adjusting for confounders, waist circumference (W) and VFA had a closer relationship with serum OCN, FGF23, and NGAL levels than body mass index (BMI) and body fat percentage (fat%, all P < 0.05). The risk of visceral obesity significantly increased with higher FGF23 and/or NGAL levels, as well as with reduced OCN levels (all P < 0.05). In addition, serum OCN, FGF23, and NGAL levels were independently associated with visceral obesity (all P < 0.01). The relationships persisted among subjects with normal glucose tolerance or subjects with hyperglycaemia (both P < 0.05).<br />Conclusions: Compared to the indicators of overall adiposity such as BMI or fat%, visceral adiposity indicators (W or VFA) were more closely related to serum OCN, FGF23 and NGAL levels. There was no interaction among the relationship of three bone-derived factors with visceral obesity, which revealed the independent relationship of endocrine function of skeleton with body fat.
- Subjects :
- Adult
Aged
Biomarkers blood
Body Mass Index
China
Enzyme-Linked Immunosorbent Assay
Female
Fibroblast Growth Factor-23
Humans
Intra-Abdominal Fat diagnostic imaging
Intra-Abdominal Fat metabolism
Magnetic Resonance Imaging
Male
Middle Aged
Obesity diagnostic imaging
Subcutaneous Fat, Abdominal diagnostic imaging
Subcutaneous Fat, Abdominal metabolism
Waist Circumference
Adiposity
Bone and Bones metabolism
Fibroblast Growth Factors blood
Intra-Abdominal Fat physiopathology
Lipocalin-2 blood
Obesity blood
Obesity physiopathology
Osteocalcin blood
Subcutaneous Fat, Abdominal physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2840
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cardiovascular diabetology
- Publication Type :
- Academic Journal
- Accession number :
- 30424752
- Full Text :
- https://doi.org/10.1186/s12933-018-0786-9