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Negative Control of RpoS Synthesis by the sRNA ReaL in Pseudomonas aeruginosa .
- Source :
-
Frontiers in microbiology [Front Microbiol] 2018 Oct 29; Vol. 9, pp. 2488. Date of Electronic Publication: 2018 Oct 29 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- Pseudomonas aeruginosa (Pae) is an opportunistic human pathogen, able to resist host defense mechanisms and antibiotic treatment. In Pae, the master regulator of stress responses RpoS (σ <superscript>S</superscript> ) is involved in the regulation of quorum sensing and several virulence genes. Here, we report that the sRNA ReaL translationally silences rpoS mRNA, which results in a decrease of the RpoS levels. Our studies indicated that ReaL base-pairs with the Shine-Dalgarno region of rpoS mRNA. These studies are underlined by a highly similar transcription profile of a rpoS deletion mutant and a reaL over-expressing strain.
Details
- Language :
- English
- ISSN :
- 1664-302X
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Frontiers in microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 30420839
- Full Text :
- https://doi.org/10.3389/fmicb.2018.02488