TRPM2 activation: Paradigm shifted?

Authors :: Fliegert R
Hölzer HT
Guse AH
Source :: Cell calcium [Cell Calcium] 2018 Dec; Vol. 76, pp. 132-134. Date of Electronic Publication: 2018 Nov 03.
Publication Year :: 2018
Abstract: Transient receptor potential cation channel, subtype melastatin 2 (TRPM2), is important for several physiological functions, such as immune response or temperature regulation. Recently, the structure of full-length TRPM2 from zebrafish was published (Huang et al., 2018) proposing a new activation mechanism - is it really a paradigm shift or just reflects evolution of the channel?.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)