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MAIT cells contribute to protection against lethal influenza infection in vivo.
- Source :
-
Nature communications [Nat Commun] 2018 Nov 09; Vol. 9 (1), pp. 4706. Date of Electronic Publication: 2018 Nov 09. - Publication Year :
- 2018
-
Abstract
- Mucosal associated invariant T (MAIT) cells are evolutionarily-conserved, innate-like lymphocytes which are abundant in human lungs and can contribute to protection against pulmonary bacterial infection. MAIT cells are also activated during human viral infections, yet it remains unknown whether MAIT cells play a significant protective or even detrimental role during viral infections in vivo. Using murine experimental challenge with two strains of influenza A virus, we show that MAIT cells accumulate and are activated early in infection, with upregulation of CD25, CD69 and Granzyme B, peaking at 5 days post-infection. Activation is modulated via cytokines independently of MR1. MAIT cell-deficient MR1 <superscript>-/-</superscript> mice show enhanced weight loss and mortality to severe (H1N1) influenza. This is ameliorated by prior adoptive transfer of pulmonary MAIT cells in both immunocompetent and immunodeficient RAG2 <superscript>-/-</superscript> γC <superscript>-/-</superscript> mice. Thus, MAIT cells contribute to protection during respiratory viral infections, and constitute a potential target for therapeutic manipulation.
- Subjects :
- Adoptive Transfer
Animals
Cytokines metabolism
Histocompatibility Antigens Class I metabolism
Humans
Lung pathology
Mice, Inbred C57BL
Minor Histocompatibility Antigens metabolism
Influenza, Human pathology
Influenza, Human virology
Mucosal-Associated Invariant T Cells virology
Orthomyxoviridae Infections pathology
Orthomyxoviridae Infections virology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 30413689
- Full Text :
- https://doi.org/10.1038/s41467-018-07207-9