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Obesity survival paradox in pneumonia supported with extracorporeal membrane oxygenation: Analysis of the national registry.
- Source :
-
Journal of critical care [J Crit Care] 2018 Dec; Vol. 48, pp. 453-457. - Publication Year :
- 2018
-
Abstract
- Purpose: To investigate whether the obesity survival paradox, where obesity is associated with improved survival, exists for pneumonia supported with extracorporeal membrane oxygenation (ECMO).<br />Materials and Methods: Between January 2014 and December 2015, 223 patients with acute respiratory failure who underwent ECMO in 11 hospitals in South Korea were enrolled retrospectively, and data relating to pneumonia cases were analyzed. Patients were divided into groups according to their pre-treatment body mass index (BMI): obese (BMI ≥ 25 kg/m <superscript>2</superscript> ) and non-obese (BMI < 25 kg/m <superscript>2</superscript> ). The BMI cut-off was adopted from the World Health Organization for Asian populations.<br />Results: In total, 84 patients had pneumonia: obese group, 26; non-obese group, 58 (mean BMI, 27.8 vs. 21.4, p < 0.001). Pre-ECMO parameters and rescue therapy did not differ between the groups. The rate of successful weaning from ECMO was not different between the groups (76.9% vs. 72.4%, p = 0.753), but survival-to-discharge (73.1% vs. 36.2%, p = 0.002) and 6-month survival (69.2% vs. 36.2%, p = 0.005) rates were higher in the obese group. After adjusting for age and the pre-treatment PaO <subscript>2</subscript> /FiO <subscript>2</subscript> ratio, low BMI was significantly associated with 6-month mortality (odds ratio 3.28, 95% confidence interval: 1.06-11.03, p = 0.044).<br />Conclusions: An obesity survival paradox exists in pneumonia supported with ECMO.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Body Mass Index
Female
Humans
Male
Middle Aged
Odds Ratio
Republic of Korea
Respiratory Distress Syndrome etiology
Respiratory Distress Syndrome mortality
Retrospective Studies
Survival Analysis
Extracorporeal Membrane Oxygenation methods
Obesity complications
Pneumonia complications
Respiratory Distress Syndrome therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8615
- Volume :
- 48
- Database :
- MEDLINE
- Journal :
- Journal of critical care
- Publication Type :
- Academic Journal
- Accession number :
- 30409352
- Full Text :
- https://doi.org/10.1016/j.jcrc.2018.08.003