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Learning Deficits in Adult Mitochondria Carrier Homolog 2 Forebrain Knockout Mouse.
- Source :
-
Neuroscience [Neuroscience] 2018 Dec 01; Vol. 394, pp. 156-163. Date of Electronic Publication: 2018 Oct 26. - Publication Year :
- 2018
-
Abstract
- Mitochondrial Carrier Homolog 2 (MTCH2) acts as a receptor for the BH3 interacting-domain death agonist (BID) in the mitochondrial outer membrane. Loss of MTCH2 affects mitochondria energy metabolism and function. MTCH2 forebrain conditional KO (MTCH2 BKO) display a deficit in hippocampus-dependent cognitive functions. Here we study age-related MTCH2 BKO behavioral and electrophysiological aspects of hippocampal functions. MTCH2 BKO exhibit impaired spatial but not motor learning and an impairment in long-term potentiation (LTP) in hippocampal slices. Moreover, MTCH2 BKO express an increase in activated microglia, in addition to a reduction in neuron density in the hippocampus, but do not express amyloid-β plaques or neurofibrillary tangles. These results highlight the role of mitochondria in the normal hippocampus-dependent memory formation.<br /> (Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Female
Hippocampus pathology
Long-Term Potentiation
Mice, Inbred C57BL
Mice, Knockout
Microglia metabolism
Motor Skills
Neurons pathology
Prosencephalon pathology
Rotarod Performance Test
Hippocampus physiopathology
Mitochondrial Membrane Transport Proteins genetics
Prosencephalon physiopathology
Spatial Learning
Subjects
Details
- Language :
- English
- ISSN :
- 1873-7544
- Volume :
- 394
- Database :
- MEDLINE
- Journal :
- Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 30401654
- Full Text :
- https://doi.org/10.1016/j.neuroscience.2018.10.035