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Differential lateral and basal tension drive folding of Drosophila wing discs through two distinct mechanisms.
- Source :
-
Nature communications [Nat Commun] 2018 Nov 05; Vol. 9 (1), pp. 4620. Date of Electronic Publication: 2018 Nov 05. - Publication Year :
- 2018
-
Abstract
- Epithelial folding transforms simple sheets of cells into complex three-dimensional tissues and organs during animal development. Epithelial folding has mainly been attributed to mechanical forces generated by an apically localized actomyosin network, however, contributions of forces generated at basal and lateral cell surfaces remain largely unknown. Here we show that a local decrease of basal tension and an increased lateral tension, but not apical constriction, drive the formation of two neighboring folds in developing Drosophila wing imaginal discs. Spatially defined reduction of extracellular matrix density results in local decrease of basal tension in the first fold; fluctuations in F-actin lead to increased lateral tension in the second fold. Simulations using a 3D vertex model show that the two distinct mechanisms can drive epithelial folding. Our combination of lateral and basal tension measurements with a mechanical tissue model reveals how simple modulations of surface and edge tension drive complex three-dimensional morphological changes.
- Subjects :
- Actins metabolism
Actomyosin
Amides antagonists & inhibitors
Animals
Biomechanical Phenomena
Body Patterning genetics
Cell Division
Cell Proliferation
Cell Shape
Cell Size
Drosophila anatomy & histology
Drosophila embryology
Drosophila genetics
Drosophila Proteins genetics
Drosophila Proteins metabolism
Epithelial Cells drug effects
Epithelium drug effects
Extracellular Matrix
Imaginal Discs growth & development
Larva cytology
Larva metabolism
Laser Therapy
Models, Anatomic
Models, Biological
Pyridines antagonists & inhibitors
Drosophila growth & development
Epithelial Cells cytology
Epithelium anatomy & histology
Epithelium embryology
Morphogenesis
Stress, Mechanical
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 30397306
- Full Text :
- https://doi.org/10.1038/s41467-018-06497-3