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In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli .
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Dec 21; Vol. 63 (1). Date of Electronic Publication: 2018 Dec 21 (Print Publication: 2019). - Publication Year :
- 2018
-
Abstract
- The in vitro activity of sulopenem was assessed against a collection from 2014 to 2016 of 539 urinary isolates of Escherichia coli from Canadian patients by using CLSI-defined broth microdilution methodology. A concentration of sulopenem 0.03 µg/ml inhibited both 50% (MIC <subscript>50</subscript> ) and 90% (MIC <subscript>90</subscript> ) of isolates tested; sulopenem MICs ranged from 0.015 to 0.25 µg/ml. The in vitro activity of sulopenem was unaffected by nonsusceptibility to trimethoprim-sulfamethoxazole and/or ciprofloxacin, multidrug-resistant phenotypes, extended-spectrum β-lactamases, or AmpC β-lactamases.<br /> (Copyright © 2018 American Society for Microbiology.)
- Subjects :
- Administration, Oral
Canada
Ciprofloxacin pharmacology
Drug Resistance, Multiple, Bacterial genetics
Escherichia coli genetics
Escherichia coli isolation & purification
Escherichia coli metabolism
Escherichia coli Infections drug therapy
Escherichia coli Infections microbiology
Humans
Microbial Sensitivity Tests
Phenotype
Retrospective Studies
Trimethoprim, Sulfamethoxazole Drug Combination pharmacology
Urinary Tract Infections drug therapy
Urinary Tract Infections microbiology
Anti-Bacterial Agents pharmacology
Drug Resistance, Multiple, Bacterial drug effects
Escherichia coli drug effects
Lactams pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 63
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 30397056
- Full Text :
- https://doi.org/10.1128/AAC.01832-18