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Progressive resistance training prevents loss of muscle mass and strength in bile duct-ligated rats.
- Source :
-
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2019 Apr; Vol. 39 (4), pp. 676-683. Date of Electronic Publication: 2018 Nov 25. - Publication Year :
- 2019
-
Abstract
- Background: Loss of muscle mass and strength is common in cirrhosis and increases the risk of hyperammonaemia and hepatic encephalopathy. Resistance training optimizes muscle mass and strength in several chronic diseases. However, the beneficial effects of resistance training in cirrhosis remain to be investigated. Bile duct-ligated (BDL) rats develop chronic liver disease, hyperammonaemia, reduced muscle mass and strength. Our aim was to test the effects of resistance training on muscle mass, function and ammonia metabolism in BDL-rats.<br />Methods: A group of BDL-rats underwent a progressive resistance training programme and a group of non-exercise BDL-rats served as controls. Resistance training comprised of ladder climbing with a progressive increase in carrying weights attached to the tail. Training was performed 5 days a week during 4 weeks. Muscle strength and body composition were assessed using grip strength and EchoMRI. Weight and circumference of the gastrocnemius muscle (normalized to bodyweight), plasma ammonia and glutamine synthetase protein expression and activity were assessed.<br />Results: BDL + exercise rats had significantly larger gastrocnemius circumference compared to non-exercise BDL-rats: ratio 0.082 vs 0.075 (P < 0.05). Gastrocnemius muscle weight was higher in exercisers than controls: 0.006 vs 0.005 (P < 0.05). A tendency towards a lower plasma ammonia in the exercise group compared to controls was observed (P = 0.10). There were no differences in lean body mass, GS protein expression and activity between the groups.<br />Conclusion: Resistance training in rats with chronic liver disease beneficially effects muscle mass and strength. The effects were followed by non-significant reduction in blood ammonia; however, a tendency was observed.<br /> (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Ammonia blood
Animals
Bile Ducts surgery
Body Composition
Disease Models, Animal
Hepatic Encephalopathy
Hyperammonemia etiology
Hyperammonemia pathology
Ligation
Male
Muscle Proteins metabolism
Rats
Rats, Sprague-Dawley
Weight Gain
Liver Cirrhosis, Experimental pathology
Muscle, Skeletal pathology
Physical Conditioning, Animal methods
Resistance Training
Subjects
Details
- Language :
- English
- ISSN :
- 1478-3231
- Volume :
- 39
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Liver international : official journal of the International Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 30394651
- Full Text :
- https://doi.org/10.1111/liv.13997