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Elevated serum levels of procollagen C-proteinase enhancer-1 in patients with chronic kidney disease is associated with a declining glomerular filtration rate.
- Source :
-
Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2019 Sep; Vol. 24 (9), pp. 938-942. Date of Electronic Publication: 2019 Apr 29. - Publication Year :
- 2019
-
Abstract
- Background: Procollagen C-proteinase enhancer-1 (PCPE-1) is a 55 kDa glycoprotein, which increases the activity of procollagen C-proteinases that break down C-terminal propeptides. Studies have shown that PCPE-1 is involved in the fibrotic process that occurs in various tissues and organs. Our review of the literature revealed no data concerning the relation between PCPE-1 and chronic kidney disease (CKD). The purpose of this study was to determine PCPE-1 levels in CKD.<br />Methods: One hundred thirty-one CKD patients and 34 healthy controls were included in our study. Demographic data were recorded, and routine biochemical tests were performed. Blood specimens were collected for PCPE-1 investigation. Demographic data, biochemical test results and PCPE-1 levels were compared between the control and patient groups. Parameters affecting PCPE-1 levels in our patient group were assessed.<br />Results: Procollagen C-proteinase enhancer-1 levels were significantly higher in our patient group compared to the control group. Parameters affecting PCPE-1 elevation in the patient group were identified as systolic blood pressure, blood urea nitrogen, phosphorus, haemoglobin, intact parathormone levels, glomerular filtration rate and body mass index.<br />Conclusion: We determined high PCPE-1 levels in CKD patients. PCPE-1 levels being negatively correlated with glomerular filtration rate suggests that PCPE-1 may be associated with progression in CKD patients.<br /> (© 2018 Asian Pacific Society of Nephrology.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers blood
Case-Control Studies
Cross-Sectional Studies
Disease Progression
Female
Humans
Male
Middle Aged
Renal Insufficiency, Chronic diagnosis
Renal Insufficiency, Chronic physiopathology
Up-Regulation
Young Adult
Extracellular Matrix Proteins blood
Glomerular Filtration Rate
Renal Insufficiency, Chronic blood
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1797
- Volume :
- 24
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nephrology (Carlton, Vic.)
- Publication Type :
- Academic Journal
- Accession number :
- 30393914
- Full Text :
- https://doi.org/10.1111/nep.13521