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MIBG myocardial scintigraphy in progressive supranuclear palsy.
- Source :
-
Journal of the neurological sciences [J Neurol Sci] 2019 Jan 15; Vol. 396, pp. 3-7. Date of Electronic Publication: 2018 Oct 22. - Publication Year :
- 2019
-
Abstract
- Background and Objectives: Meta-iodobenzylguanidine (MIBG) myocardial scintigraphy is an effective tool for distinguishing Parkinson's disease (PD) from other diseases accompanied by parkinsonism. Unlike other Parkinsonian diseases, in PD, MIBG accumulation in the heart tends to decrease. However, previous studies have reported that a decrease in MIBG accumulation also occurs in progressive supranuclear palsy (PSP). Thus, we analyzed the relationship between the degree of MIBG accumulation decrease, clinical symptoms, and brainstem atrophy in PSP.<br />Methods: We retrospectively collected data from patients who underwent MIBG myocardial scintigraphy and compared MIBG indices (heart to mediastinum [H/M] ratio, washout rate) between subjects with PSP and other diseases including PD. In addition, we evaluated the relationship between clinical characteristics, MIBG accumulation, and brainstem atrophy in patients with PSP.<br />Results: Patients with PSP had a significantly lower early H/M ratio compared with multiple system atrophy with predominant parkinsonism (MSA-P) patients, and a control group. In PSP patients there was a correlation between the decrease in delay H/M ratio, atrophy of the pons, and clinical severity as evaluated by Hoehn and Yahr score.<br />Conclusion: Unlike in PD, PSP patients exhibited a mild decrease in MIBG accumulation in MIBG myocardial scintigraphy, which may be related to brainstem atrophy.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Atrophy etiology
Brain Stem pathology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multiple System Atrophy diagnostic imaging
Parkinson Disease diagnostic imaging
Retrospective Studies
3-Iodobenzylguanidine metabolism
Myocardial Perfusion Imaging methods
Radiopharmaceuticals metabolism
Supranuclear Palsy, Progressive diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5883
- Volume :
- 396
- Database :
- MEDLINE
- Journal :
- Journal of the neurological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30391822
- Full Text :
- https://doi.org/10.1016/j.jns.2018.10.019