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Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice.
- Source :
-
Neuroscience research [Neurosci Res] 2019 Oct; Vol. 147, pp. 58-63. Date of Electronic Publication: 2018 Nov 02. - Publication Year :
- 2019
-
Abstract
- Huntington Disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the exon1 of huntingtin gene (HTT). The mutant HTT affects the transcriptional profile of neurons by disrupting the activities of transcriptional machinery and alters expression of many genes. In this study, we identified dysregulated non-coding RNAs (ncRNAs) in medium spiny neurons of 4-week-old HD model mouse. Also, we observed the intracellular localizations of Abhd11os and Neat1 ncRNAs by ViewRNA in situ hybridization, which could provide more precise detection, suggesting that it is a useful method to investigate the expression changes of genes with low expression levels.<br /> (Copyright © 2018 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.)
- Subjects :
- Animals
Brain metabolism
Corpus Striatum metabolism
Disease Models, Animal
Dopamine and cAMP-Regulated Phosphoprotein 32 metabolism
Gene Expression
Humans
Huntington Disease genetics
Huntington Disease pathology
In Situ Hybridization
Mice
Mice, Transgenic
Neurons pathology
RNA, Long Noncoding genetics
RNA, Long Noncoding metabolism
Serine Proteases genetics
Serine Proteases metabolism
Transcriptome
Huntington Disease metabolism
Neurons metabolism
RNA, Long Noncoding biosynthesis
Serine Proteases biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8111
- Volume :
- 147
- Database :
- MEDLINE
- Journal :
- Neuroscience research
- Publication Type :
- Academic Journal
- Accession number :
- 30391555
- Full Text :
- https://doi.org/10.1016/j.neures.2018.10.013