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Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population.

Authors :
Chiesa Fuxench ZC
Block JK
Boguniewicz M
Boyle J
Fonacier L
Gelfand JM
Grayson MH
Margolis DJ
Mitchell L
Silverberg JI
Schwartz L
Simpson EL
Ong PY
Source :
The Journal of investigative dermatology [J Invest Dermatol] 2019 Mar; Vol. 139 (3), pp. 583-590. Date of Electronic Publication: 2018 Oct 30.
Publication Year :
2019

Abstract

Population-based estimates on the prevalence of atopic dermatitis in adults vary widely. The objectives of this study were to determine the prevalence of atopic dermatitis in the population of the United States, the distribution of disease severity, and its impact on health-related quality of life. Among 1,278 participating adults, the prevalence (95% confidence interval) of atopic dermatitis was 7.3% (5.9-8.8). Overall, 60.1% (56.1-64.1) of participants were classified as having mild, 28.9% (25.3-32.7) as having moderate, and 11% as having severe (8.6-13.7) disease. Patients with atopic dermatitis and those with more severe disease had higher scores in the dermatology life quality index (mean [standard deviation] for AD patients = 4.71 [6.44] vs. control individuals = 0.97 [2.12]) (P < 0.001) and the hospital anxiety (mean [standard deviation] for AD patients = 7.03 [4.80] vs. control individuals = 4.73 [4.8]) and depression (mean, [standard deviation] for AD patients = 5.83 [4.54] vs. control individuals = 3.62 [3.61]) scales, indicating a worse impact on quality of life and an increased likelihood of anxiety or depression. Based on our prevalence estimates, 16.5 million adults would have a diagnosis of atopic dermatitis, with 6.6 million meeting criteria for moderate to severe disease. Our study confirms the high prevalence and disease burden of atopic dermatitis in this population.<br /> (Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1523-1747
Volume :
139
Issue :
3
Database :
MEDLINE
Journal :
The Journal of investigative dermatology
Publication Type :
Academic Journal
Accession number :
30389491
Full Text :
https://doi.org/10.1016/j.jid.2018.08.028