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Increased eryptosis in smokers is associated with the antioxidant status and C-reactive protein levels.
- Source :
-
Toxicology [Toxicology] 2019 Jan 01; Vol. 411, pp. 43-48. Date of Electronic Publication: 2018 Oct 29. - Publication Year :
- 2019
-
Abstract
- Cigarette smoking has been linked with oxidative stress and inflammation. In turn, eryptosis, the suicidal erythrocyte death similar to apoptosis that can be triggered by oxidative stress, has been associated with chronic inflammatory diseases including atherosclerosis. However, the link between smoking and eryptosis has not been explored so far. The aim of the present study was to determine the level of eryptotic erythrocytes in healthy male smokers (n = 21) compared to non-smokers (n = 21) and assess its relationship with systemic inflammation (CRP) as well as with antioxidant defense (GSH) and their resistance to ex-vivo induced hemolysis. Smoking caused an increase in phosphatidylserine translocation outside the erythrocyte membrane (hallmark of eryptosis), significantly correlated to the plasma level of CRP (r = 0.546) and GSH concentration in erythrocytes (r=-0.475). With respect to non-smokers, smokers show a marginal increase of total leucocytes and erythrocyte volume, no modifications of the RBC resistance to oxidative stress-induced hemolysis and hematological and lipid parameters unvaried. We conclude that the inflammatory status (high CRP levels) and RBC oxidative stress (low GSH levels) caused by cigarette smoking are associated with an increase of eryptotic erythrocytes, a yet unknown relationship potentially involved with atherosclerosis and cardiovascular disease in smokers.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Cross-Sectional Studies
Erythrocyte Membrane drug effects
Erythrocyte Membrane metabolism
Glutathione blood
Health Status
Hemolysis drug effects
Humans
In Vitro Techniques
Leukocyte Count
Male
Middle Aged
Oxidative Stress drug effects
Phosphatidylserines blood
Young Adult
Antioxidants metabolism
C-Reactive Protein metabolism
Eryptosis
Smokers
Smoking adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-3185
- Volume :
- 411
- Database :
- MEDLINE
- Journal :
- Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 30385265
- Full Text :
- https://doi.org/10.1016/j.tox.2018.10.019