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Mathematical insights on psoriasis regulation: Role of Th₁ and Th₂ cells.
- Source :
-
Mathematical biosciences and engineering : MBE [Math Biosci Eng] 2018 Jun 01; Vol. 15 (3), pp. 717-738. - Publication Year :
- 2018
-
Abstract
- Psoriasis is an autoimmune disorder, characterized by hyper-proli-feration of Keratinocytes for the abnormal activation of T Cells, Dendritic Cells (DCs) and cytokine signaling. Interaction of DCs and T Cells enable T Cell to differentiate into Type 1 (Th₁), Type 2 (Th₂) helper T Cell depending on cytokine release. Hyper-proliferation of Keratinocytes may occur due to over expression of pro-inflammatory cytokines secreted by Th₁-Cells viz. Interferon gamma (IFN-γ), Transforming growth factor beta (TGF-β) and Tumor necrosis factor alpha (TNF-α) etc. Deregulation of epidermal happens due to signaling of anti-inflammatory cytokines like Interleukin 10 (IL-10), Interleukin 4 (IL-4) etc., released by Th₂-Cells. In this article, we have constructed a set of nonlinear differential equations involving the above cell population for better understanding the impact of cytokines on Psoriasis. System is analyzed introducing therapeutic agent (Biologic / IL-10) for reducing the hyper-proliferation of Keratinocytes. Effect of Biologic is used as a surrogate of control parameter to reduce the psoriatic lesions. We also studied its effect both in continuous and impulsive dosing method. Our study reveals that impulsive dosing is more applicable compare with continuous dosing to prevent Psoriasis.
- Subjects :
- Computer Simulation
Cytokines immunology
Dendritic Cells immunology
Humans
Interleukin-10 immunology
Interleukin-10 therapeutic use
Keratinocytes immunology
Keratinocytes pathology
Mathematical Concepts
Nonlinear Dynamics
Psoriasis pathology
Psoriasis therapy
Recombinant Proteins immunology
Recombinant Proteins therapeutic use
Models, Immunological
Psoriasis immunology
Th1 Cells immunology
Th2 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1551-0018
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Mathematical biosciences and engineering : MBE
- Publication Type :
- Academic Journal
- Accession number :
- 30380327
- Full Text :
- https://doi.org/10.3934/mbe.2018032