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Morphoproteomics and Biomedical Analytics Identify the c-Myc, EZH2, Sirt1 and CXCR4 Pathways as Potential Blocks to Differentiation Leading to Proliferation and Metastatic Potential in Sinonasal Undifferentiated Carcinoma (SNUC) and Provide Therapeutic Options: A Case Study.
- Source :
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Annals of clinical and laboratory science [Ann Clin Lab Sci] 2018 Sep; Vol. 48 (5), pp. 659-664. - Publication Year :
- 2018
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Abstract
- Sinonasal undifferentiated carcinoma (SNUC) is a highly malignant tumor in the nasal cavity or paranasal sinuses. Morphoproteomics has defined its biology to some degree, allowing the identification of targeted therapeutic options with clinical efficacy [1]. This study's objective was to identify putative SNUC pathways that are known to pose a block in differentiation both in early embryogenesis and in tumorigenesis or that might promote metastasis and recurrent disease.<br />Design: Morphoproteomic analysis of SNUC from a case study of this patient included immunohistochemical probes to detect c-Myc, EZH2, Sirt1 and CXCR4 protein analytes. Biomedical analytics schematically showed the interactions of these analytes with the morphoproteomic findings and illustrated targeted therapeutic options.<br />Results: Representative sections of this patient's tumor displayed plasmalemmal expression for CXCR4 and nuclear immunopositivity for c-Myc, EZH2, and Sirt1. This coincided with their block in differentiation and their proliferative state with progression into the mitotic phase. Biomedical analytics integrated the morphoproteomic findings with the undifferentiated and proliferative state of SNUC and depicted pharmacogenomic and other related factors that target the c-Myc, EZH2, Sirt1 and CXCR4 pathways.<br />Conclusion: Morphoproteomics and biomedical analytics have identified c-Myc, EZH2, Sirt1 and CXCR4 pathways that collectively could contribute to the block in differentiation and increase the propensity for recurrence and metastasis in SNUC. This suggests that combinatorial therapies modulating these pathways could be used in a maintenance mode to minimize the risk of recurrent disease.<br /> (© 2018 by the Association of Clinical Scientists, Inc.)
- Subjects :
- Carcinoma chemistry
Carcinoma therapy
Cell Proliferation
Enhancer of Zeste Homolog 2 Protein analysis
Humans
Maxillary Sinus Neoplasms chemistry
Maxillary Sinus Neoplasms therapy
Neoplasm Metastasis
Proto-Oncogene Proteins c-myc analysis
Receptors, CXCR4 analysis
Sirtuin 1 analysis
Carcinoma pathology
Enhancer of Zeste Homolog 2 Protein physiology
Maxillary Sinus Neoplasms pathology
Proteomics methods
Proto-Oncogene Proteins c-myc physiology
Receptors, CXCR4 physiology
Signal Transduction physiology
Sirtuin 1 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-8080
- Volume :
- 48
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Annals of clinical and laboratory science
- Publication Type :
- Academic Journal
- Accession number :
- 30373873