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Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trial.
- Source :
-
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne [CMAJ] 2018 Oct 29; Vol. 190 (43), pp. E1273-E1280. - Publication Year :
- 2018
-
Abstract
- Background: Curcumin, a popular herbal supplement from the plant turmeric, has prevented ischemic reperfusion and toxin-induced injury in many animal studies and a single-centre randomized human trial. We sought to test whether perioperative oral curcumin (compared with placebo) affects the inflammatory response and risk of postrepair complications after elective abdominal aortic aneurysm repair in humans.<br />Methods: We conducted a parallel-group, randomized, placebo-controlled trial of patients from 10 hospitals in Canada who were scheduled to undergo elective repair of an unruptured abdominal aortic aneurysm (November 2011 to November 2014). Patients in the treatment group received perioperative oral curcumin (2000-mg doses 8 times over 4 d). Patients, health care providers and local research staff were unaware of the treatment assignment. The primary outcomes were median concentrations of 4 bio markers indicating injury and inflammation (postoperative urine interleukin-18 and perioperative rise in serum creatinine, plasma N -terminal pro-B-type natriuretic peptide and plasma high-sensitivity C-reactive protein).<br />Results: Baseline characteristics were similar in the 2 groups (606 patients overall; median age 76 yr). More than 85% of patients in each group took more than 80% of their scheduled capsules. Neither curcumin nor placebo significantly affected any of the 4 biomarkers ( p > 0.05 for all comparisons). Regarding the secondary outcomes, there was a higher risk of acute kidney injury with curcumin than with placebo (17% v. 10%, p = 0.01), but no between-group difference in the median length of hospital stay (5 v. 5 days, p > 0.9) or the risk of clinical events (9% v. 9%, p = 0.9).<br />Interpretation: Curcumin had no beneficial effects when used in elective abdominal aortic aneurysm repair. These findings emphasize the importance of testing turmeric and curcumin before espousing their health benefits, as is currently done in the popular media.<br />Trial Registration: ClinicalTrials.gov, no. NCT01225094.<br />Competing Interests: Competing interests: P.J. Devereaux has received grants from Abbott Diagnostics, Boehringer Ingelheim, Covidien, Octopharma, Philips Healthcare, Roche Diagnostics amd Stryker for projects outside the work reported here. Matthew James is the principal investigator on an investigator-initiated research grant funded by Amgen Canada outside the work reported here. No other competing interests were declared.<br /> (© 2018 Joule Inc. or its licensors.)
- Subjects :
- Administration, Oral
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Biomarkers blood
C-Reactive Protein analysis
Creatinine blood
Curcumin adverse effects
Double-Blind Method
Elective Surgical Procedures methods
Female
Humans
Interleukin-18 urine
Male
Natriuretic Peptide, C-Type blood
Perioperative Care methods
Treatment Outcome
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Aortic Aneurysm, Abdominal surgery
Curcumin administration & dosage
Postoperative Complications prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1488-2329
- Volume :
- 190
- Issue :
- 43
- Database :
- MEDLINE
- Journal :
- CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
- Publication Type :
- Academic Journal
- Accession number :
- 30373740
- Full Text :
- https://doi.org/10.1503/cmaj.180510