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Colon cancer patients with a serious psychiatric disorder present with a more advanced cancer stage and receive less adjuvant chemotherapy - A Nationwide Danish Cohort Study.
- Source :
-
BMC cancer [BMC Cancer] 2018 Oct 29; Vol. 18 (1), pp. 1050. Date of Electronic Publication: 2018 Oct 29. - Publication Year :
- 2018
-
Abstract
- Background: Psychiatric patients with colorectal cancer may have delayed diagnosis and be oncologically undertreated.<br />Methods: The Danish Colorectal Cancer Group database comprised 25,194 colorectal cancer patients (CRC), (colon cancer (CC, n = 16,641), rectal cancer (RC, n = 8553)), having an operation in 2007-2013, were alive at least 30 days after operation, of which 422 have had at least one hospital contact for a serious psychiatric disorder; ICD-10: DF20-29: primary psychotic disorders, or DF30-39: affective disorders (exposed) in a period of 3650-120 days before the operation date. Pearson chi-squared test for cancer stage was calculated. Odds Ratio (OR) with 95% confidence interval (CI) for having had a palliative vs an intended curative aim of the operative treatment for CRC patients (cohort 1), and for having an oncological treatment for each cancer site CC or RC (cohort 2 and 3) in patients with and without a psychiatric history was estimated. We adjusted the OR for: age, gender, comorbidity index, cancer stage, socio-economic position group, and educational level.<br />Results: A higher cancer stage at the time of operation in patients with psychiatric disorders compared with patients without such a history was seen and may possibly point towards a delay in the diagnosis or in the treatment of CC in patients with psychiatric disorders. They also had decreased adjusted OR for having an oncological treatment, OR 0.55, 95% CI (0.40-0.76)), which was not explained by cancer stage. For patients with RC no difference was seen.<br />Conclusions: Attention for CC patients with pre-existing serious psychiatric disorders is recommended.
- Subjects :
- Chemotherapy, Adjuvant adverse effects
Cohort Studies
Colonic Neoplasms drug therapy
Colonic Neoplasms pathology
Comorbidity
Databases, Factual
Denmark epidemiology
Female
Humans
Male
Neoplasm Staging
Population Surveillance
Registries
Colonic Neoplasms complications
Colonic Neoplasms epidemiology
Mental Disorders epidemiology
Mental Disorders etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 18
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30373562
- Full Text :
- https://doi.org/10.1186/s12885-018-4879-3